Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans

Dipeptidyl-peptidase IV secreted by Aspergillus fumigatus, a fungus pathogenic to humans.

A dipeptidyl-peptidase IV was purified from the culture medium of the human-pathogenic fungus Aspergillus fumigatus. The enzyme has an apparent molecular mass of 95 kDa and contained approximately 10 kDa of N-linked carbohydrate. This glycoprotein is antigenic and has all characteristics of the class IV dipeptidyl-peptidases: removal of Xaa-Pro and to a lesser extent Xaa-Ala dipeptides from the...

Aspergillus fumigatus, a saprotrophic pathogenic fungus

Aspergillus fumigatus is the most common and life-threatening aerial fungal pathogen, especially among immunocompromised hosts. Understanding the pathobiology of this pathogen requires investigations both to characterise the immunosuppressive status of the phagocytic cells that usually kill the fungus in the immunocompetent host, and to identify fungal virulence factors that either promote the ...

Genomic Islands in the Pathogenic Filamentous Fungus Aspergillus fumigatus

We present the genome sequences of a new clinical isolate of the important human pathogen, Aspergillus fumigatus, A1163, and two closely related but rarely pathogenic species, Neosartorya fischeri NRRL181 and Aspergillus clavatus NRRL1. Comparative genomic analysis of A1163 with the recently sequenced A. fumigatus isolate Af293 has identified core, variable and up to 2% unique genes in each gen...

Multilocus sequence typing of the pathogenic fungus Aspergillus fumigatus.

A multilocus sequence typing (MLST) scheme was devised for Aspergillus fumigatus. The system involved sequencing seven gene fragments and was applied to a panel of 100 isolates of A. fumigatus from diverse sources. Thirty different sequence types were found among the 100 isolates, and 93% of the isolates differed from the other isolates by only one allele sequence, forming a single clonal clust...

Targeting Dipeptidyl Peptidase IV (CD26)